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|United States Patent||6,384,015|
|Pishevar||May 7, 2002|
The invention provides methods and compositions for inhibiting the development of intracellular parasites by treating such cells with an effective concentration of a magainin, PGLa or XPF peptide under conditions whereby the development of the parasite in the cell is inhibited. The targeted parasites have been found to increase in the accessibility of the plasma membrane of said cell to the peptide, and particularly, to effect an increase in the cytopathic, especially lytic, sensitivity of the cell to the peptide. In one application, the invention provides methods for treating blood infected with a Plasmodium species, by contacting the blood with magainin 2 under conditions whereby the development of the Plasmodium in the infected erythrocytes is inhibited and the infected erythrocytes evidence relatively increased cytolytic sensitivity to the magainin.
|Inventors:||Pishevar; Shervin K. (Oakland, CA)|
|Assignee:||The Regents of the University of California (Oakland, CA) |
|Filed:||April 1, 1997|
|Current U.S. Class:||514/12 ; 514/2|
|Current International Class:||A61K 38/17 (20060101)|
|Field of Search:||514/2,12|
Magowan et al. Blood, 86, 3196-3204, Oct. 1995.* .
Gwadz, R. et al. Infection and Immunity, 57, 2628-2633, Sep. 1989.* .
Matsuzaki et al., Biochemistry,34,6521-6526, 1995.* .
Matsuzaki et al., Biochemistry,34,12553-12559, 1995.* .
Matsuzaki et al., Biochemistry,34,3423-3429, 1995.* .
Cabantchik et al. Blood Cells, 16, (2-3), 421-432, Feb. 1990.* .
Pasvol, G. et al. Annals Tropical Medicine and Parasitology, 72, 87-88, Jan. 1978..
|United States Patent||7,124,107|
|Pishevar , et al.||October 17, 2006|
A collective procurement management system which permits multiple potential purchasers of a specific item or service to submit orders for the item or service on an ongoing basis. As orders enter the system, they are grouped such that potential purchasers are may "cooperate" in generating a collective bulk order so that all participants may obtain discount/volume pricing. Once a threshold level of order volume is obtained as a result of multiple orders, the grouped order is submitted to the supplier for fulfillment. The order is then fulfilled at a volume pricing level although individual portions of the collective order are routed to a plurality of purchasers. The present invention also includes a Reverse Auction Process (RAP) which, in one embodiment, operates to allow potential purchasers to select a product or service and set a maximum price that they are willing to pay for the same. Following submission of this information to the system, possibly including orders for the same item from other potential buyers, potential vendors bid to supply the item to the relevant buyers requesting the item.
|Inventors:||Pishevar; Shervin (Gaithersburg, MD), Morris; Drew E. (Alpine, NJ)|
|Assignee:|| Freewebs Corporation (Silver Spring, MD) |
|Filed:||June 7, 1999|
|Current U.S. Class:||705/37 ; 705/26|
|Current International Class:||G06Q 40/00 (20060101)|
|Field of Search:||705/37|
|6260025||July 2001||Silverman et al.|
|6466919||October 2002||Walker et al.|
|6606608||August 2003||Bezos et al.|
|2002/0143692||October 2002||Heimermann et al.|
|2004/0204987||October 2004||Hill et al.|
|2005/0010521||January 2005||Muelier et al.|
|2005/0234808||October 2005||Goto et al.|
Parity Trademark History, Aug. 1992, 31 pages. cited by examiner.
|United States Patent||7,085,825|
|Pishevar , et al.||August 1, 2006|
An apparatus, method and system to enable dynamic replication of Web servers across a wide area in response to access patterns by Web clients as well as in response to customer requests. The method for dynamically replicating one or more parent nodes on a network in response to a user request by a policy manager. The policy manager transmits the user request to an event module. The event module transmits the user request to a data consistency module, wherein the data consistency module maintains integrity of the data on the parent node. The event system communicates with a resource management module to ensure proper utilization of network resources, and transmits the routing request to a request routing module for appropriately balancing the network load. The request routing module is capable of providing optimal routing based on the network resources.
|Inventors:||Pishevar; Shervin (Kensington, MD), Bloch; Lewis (Catonsville, MD), Morris; Drew (Alpine, NJ), Savarese; Daniel F. (Columbia, MD), Walsh; Kevin Andrew (Raleigh, NC)|
|Filed:||May 4, 2001|
|Current U.S. Class:||709/221 ; 709/204; 709/220; 709/222; 709/226; 709/238; 709/241; 718/100; 718/101; 718/102; 718/103; 718/104; 718/105; 718/106|
|Current International Class:||G06F 15/177 (20060101)|
|Field of Search:||709/204,238,241,220-222,226 718/100-106|
||6195680||February 2001||Goldszmidt et al.|
||6424992||July 2002||Devarakonda et al.|
||6587866||July 2003||Modi et al.|
||2002/0078263||June 2002||Darling et al.|
||2002/0194251||December 2002||Richter et al.|
||2002/0199014||December 2002||Yang et al.|
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